The Use of Medium-Chain Triglycerides in Gastrointestinal Disorders

INTRODUCTION Medium-chain triglycerides (MCTs) comprise a glycerol molecule attached to 3 fatty acid chains ranging between 6 to 12 carbons in length. Unlike most other lipid molecules that require a complex process of digestion, MCTs are more easily absorbed into the bloodstream from the gastrointestinal tract. These features of MCTs confer unique benefits in the management of gastrointestinal disorders.1 As such, MCTs have historically been used to treat steatorrhea resulting from malabsorptive disorders, such as pancreatic insufficiency, prior gastrectomy and small bowel resection. MCTs have also been investigated for their potential to reduce obesity, cardiovascular disease, and neurological disorders. The purpose of this review is to describe the composition, functional characteristics and sources of MCTs, as well as to review the evidence investigating the use of MCTs in the management of gastrointestinal disorders.